Rabbit Anti-GNB5 antibody - 100 ul (1mg/ml)

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    Product NameGNB5
    AliasFLJ37457; FLJ43714; G protein beta 5 subunit; G protein beta subunit 5L; GB 5; GB5; GBB5_HUMAN; Gbeta5; GNB 5; GNB5; Guanine nucleotide binding protein (G protein) beta 5; Guanine nucleotide binding protein beta 5; Guanine nucleotide binding protein beta 5 subunit; Guanine nucleotide binding protein beta subunit 5L; Guanine nucleotide binding protein subunit beta 5; Guanine nucleotide-binding protein subunit beta-5; Transducin beta chain 5.  
    Research AreaCell biology  Signal transduction  G protein-coupled receptor  G protein signal  
    Host species
    Rabbit
    ClonalityPolyclonal
    React SpeciesHuman; Predicted: Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep
    ApplicationsELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    Theoretical molecular weight44kDa
    Cellular localizationcytoplasmic The cell membrane 
    FormLiquid
    Concentration1mg/ml
    immunogenKLH conjugated synthetic peptide derived from human GNB5: 51-150/395 
    LsotypeIgG
    Purificationaffinity purified by Protein A
    Buffer Solution0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    StorageShipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    AttentionThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMedPubMed
    Product DetailHeterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008].

    Function:
    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    Subunit:
    G proteins are composed of 3 units, alpha, beta and gamma. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) and RGS9BP (By similarity).

    Tissue Specificity:
    Expressed in multiple tissues.

    Similarity:
    Belongs to the WD repeat G protein beta family.
    Contains 7 WD repeats.

    SWISS:
    O14775

    Gene ID:
    10681

    Database links:

    Entrez Gene: 10681 Human

    Entrez Gene: 14697 Mouse

    Entrez Gene: 83579 Rat

    Omim: 604447 Human

    SwissProt: O14775 Human

    SwissProt: P62881 Mouse

    SwissProt: P62882 Rat

    Unigene: 155090 Human

    Unigene: 17604 Mouse

    Unigene: 23042 Rat


    Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GNB5) Polyclonal Antibody, Unconjugated (0812-SL13466R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining:


    Datasheet: