Description: Recombinant Human Interleukin-6/IL-6 is produced by E.coli expression system and the target gene is expressed.
Accession: P05231
Known As: Interleukin-6; IL-6; B-Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta-2; IFN-Beta-2; IL6; IFNB2
Mol Mass: 20.8kDa
APMol Mass: 20kDa, reducing conditions
Formulation: Supplied lyophilized from a 0.2 μm filtered solution of PBS, pH7.4
Purity-SDS-PAGE: >95%
Bioactivity Data: Not available
Storage: Reconstituted protein solution should be stored at ≤ -20°C.
Stable for at least 24 months when stored as instructed.
Shipping: The product is shipped on ice packs or, upon request, on dry ice. Upon receipt, store it immediately at -20°C.
Background
Cytokines of the IL6/GCSF/MGF family are glycoproteins of about 170 to 180 amino acid residues that contain four conserved cysteine residues involved in two disulfide bonds. They have a compact, globular fold (similar to other interleukins), stabilized by the 2 disulfide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist; the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.
For Research or Manufacturing Use Only, Not for Use in Diagnostic or Therapeutic Procedures.